CCR Landmarks

LANDMARKS COVER ART CREDITS

THE HPV VACCINE • Yasumoto S, et al. J Virol. 1986;57(2):572-7. • Kirnbauer R, et al. PNAS. 1992;89(24):12180-12184. • Kirnbauer R, et al. J Virol. 1993;67(12):6929-36. • Breitburd F, et al. J Virol. 1995;69(6):3959-63. • Harro CD, et al. J Natl Cancer Inst. 2001;93(4): 284-292. • Lowy DR, Schiller JT. J Clin Invest. 2006;116(5): 1167-73. • Hildesheim A, et al. JAMA. 2007;298(7):743-753. DISCOVERY OF TGF- β • Chang EH, et al. Science. 1980;210(4475):1249-51. • Chang EH, et al. Nature. 1982;297(5866):479-83. • Cooper CS, et al. Nature. 1984;311(5981):29-33. • Dean M, et al. Nature. 1985;318(6044):385-8. • Sporn MB, et al. Science. 1986;233(4763):532-4. • Velu TJ, et al. Science. 1987;238(4832):1408-10. • Rubin JS, et al. PNAS. 1989;86(3):802-6. • Bottaro DP, et al. Science. 1991;251(4995):802-4. CHROMATIN PIONEERS • Richard-Foy H, Hager GL. EMBO J. 1987;6(8): 2321-8. • Archer TK, et al. Science. 1992;255(5051):1573-6. • Tsukiyama T, et al. Nature. 1994;367:525–532. • Tsukiyama T, Wu C. Cell. 1995;83:1011–1020. • Tsukiyama T, et al. Cell. 1995;83:1021–1026. CYTOKINES AS THERAPY * included in timeline • Morgan DA, et al. Science. 1976;193(4257):1007-8. * • Leonard WJ, et al. Nature. 1984;311:626-31. * • Rosenberg SA, et al. N Engl J Med. 1988;319(25):1676-80. • Matsushima K, et al. J Exp Med. 1988;167(6): 1883-93. * • Burton JD, et al. PNAS. 1994;91(11):4935-9. * • Johnston JA, et al. Nature. 1994;370(6485):151-3. * • Kawamura M, et al. PNAS. 1994; 91(14): 6374-8. * • Sportès C, et al. Clin Cancer Res. 2010;16(2): 727-35. * • Sportès C, et al. J Exp Med. 2008;205(7):1701-14. • Conlon KC, et al. J Clin Oncol. 2015;33(1):74-82. * DEVELOPMENT OF CANCER IMMUNOTHERAPY * included in timeline • Potter M, Boyce CR. Nature. 1962;193:1086-7. * • Rosenberg SA, et al. N Engl J Med. 1985;313(23):1485-92.* • Chaudhary VK, et al. Nature. 1989;339(6223): 394-7. * • Onda M, et al. J Immunother. 2001;24(2):144-150. * • Dudley ME, et al. Science. 2002;98(5594):850-4. • Phan GQ, et al. PNAS. 2003;100(14):8372-7. * SELECTED REFERENCES

LEFT SIDE FROM TOP TO BOTTOM: Title: Killer T cells surround a cancer cell Credit: Alex Ritter, Jennifer Lippincott Schwartz and Gillian Griffiths, NIH Title: Enzyme repairing DNA Credit: Tom Ellenberger, Washington University School of Medicine in St. Louis; Dave Gohara, Saint

RIGHT SIDE FROM TOP TO BOTTOM:

• Morgan RA, et al. Science. 2006;14(5796):126-9. * • Kochenderfer JN, et al. Blood. 2010;116(19): 3875-86. * • Kreitman RJ, et al. J Clin Oncol. 2012;30(15):1822-8. • Robbins PF, et al. Nat Med. 2013;19(6):747-52. * • Tran E, et al. Science. 2014;344(6184):641-5. * GENOMIC CLASSIFICATION OF TUMORS • Zbar B, et al. Nature. 1987;327(6124):721-4. • Linehan WM, et al. JAMA. 1995;273(7):564-70. • Emmert-Buck MR, et al. Science. 1996;274(5289):998-1001. • Schmidt L, et al. Nat Genet. 1997;16(1):68-73. • Alizadeh AA, et al. Nature. 2000;403(6769):503-11. • Wright G, et al. PNAS. 2003;100(17):9991-6. • Dave SS, et al. N Engl J Med. 2004;351(21):2159-69.  CELLULAR IMAGING • Schröck E, et al. Science. 1996;273(5274):494-7. • Liyanage M, et al. Nat Genet. 1996;14(3):312-5. • Phair and Misteli, Nature , 2000;404(6778):604-9. • Meaburn KJ, et al. J Cell Biol. 2009;187(6):801-1. • Roukos V, et al. Science. 2013;341(6146):660-4. • Bartesaghi A, et al. Science. 2015;348(6239):1147-51. • Meyerson JR, et al. Nature. 2016;537(7621):567-571. THE FIRST AIDS DRUGS • Yarchoan R, et al. Lancet. 1987;1:132-5. • Yarchoan R, et al. Lancet . 1988;1:76-81. • Yarchoan R, et al. N Engl J Med. 1989;321(11): 726-38. • Yarchoan R, et al. Science. 1989;245(4916):412-5. • Miller M, et al. Science. 1989;246(4934):1149-52. • Jacobo-Molina A, et al. PNAS. 1993;90(13):6320-4. • Koh Y, et al. Antimicrob Agents Chemother. 2003;47(10):3123-9. PRECISE CLINICAL IMAGING OF TUMORS • Murugesan R, et al. Magn Reson Med. 1997;38(3):409-14. • Kuppusamy P, et al. Cancer Res. 1998;58(7):1562-8. • Singh AK, et al. BJU Int. 2008;101(7):841-5. • Hyodo F, et al. J Pharm Pharmacol. 2008;60(8):1049-60. • Turkbey B, et al. Cancer Imaging. 2011;11:31-6. CCR BY THE NUMBERS • FY 2008-17: New Employee Invention Reports, Issued U.S. patents, Active licenses, Active Cooperative Research and Development Agreements (CRADAs) • FY 2015-17: Trainees, Clinical trials, New patients, New trials opening

Title: T lymphocyte Credit: NIAID, NIH Title: Researcher in CCR lab Credit: Rhoda Baer Title: Human papillomavirus Credit: Veronica Falconieri, CCR, NCI, NIH Title: HIV infecting a human cell Credit: Seth Pincus, Elizabeth Fischer and Austin Athman, NIAID, NIH Title: Improving resolution by cryo-EM Credit: Veronica Falconieri, Sriram Subramaniam, CCR, NCI, NIH

Louis University School of Medicine Title: Terry Fry, M.D., and patient Credit: Daniel Soñe Title: Dendritic cell with HIV Credit: Donald Bliss, National Library of Medicine, NIH

CONTRIBUTORS Brenda Boersma-Maland Li Gwatkin Abbie Harrison Jessica Johnson Diana Linnekin Jennifer Michalowski Michael Miller

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